Linking Smads and transcriptional activation
نویسندگان
چکیده
منابع مشابه
Linking Smads and transcriptional activation.
TGF-beta1 (transforming growth factor-beta1) is the prototypical member of a large family of pleiotropic cytokines that regulate diverse biological processes during development and adult tissue homoeostasis. TGF-beta signals via membrane bound serine/threonine kinase receptors which transmit their signals via the intracellular signalling molecules Smad2, Smad3 and Smad4. These Smads contain con...
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The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by initiating new programs of gene expression. The best understood signal transducers for these ligands are the SMADs, which essentially act as transcription factors that are activated in the cytoplasm and then accumulate in the nucleus in response to ligand induction where they bind to enhancer/promoter ...
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Programs in Cell Biology and Developmental Biology ence with Smad signaling inhibits the ligand-induced response, Smads are considered as effectors for the ligand-induced transcriptional responses. Recent progress provides insight into the mechanisms through which Smads regulate transcription and explains the sequence heterogeneity of the TGF-/activin-respon-Smads are a class of proteins that ...
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Tag der mündlichen Prüfung am: The voyage of discovery is not in seeking new landscapes but in having new eyes-Marcel Proust ABBREVIATIONS 6 Abbreviations ADAM 1-aminoadamantam ADP Adenosine diphosphate ATP Adenosine triphosphate AHT Anhydrotetracycline Amp r Resistance towards ampicilin aphA3, Kan r Resistance towards kanamycin APS Ammoniumperoxodisulfate bp Base pairs BCA Bicinchoninic acid c...
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Transcriptional regulation is all about getting RNA polymerase to the right place on the gene at the right time and making sure that it is competent to conduct transcription. Traditional views of this process place most of their emphasis on the events that precede initiation of transcription. We imagine a promoter-bound transcriptional activator (or collection of activators) recruiting componen...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2005
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20042133